Description

5-Bromo-3-Trifluoromethylbenzo[B]Thiophene-2-Carboxylic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block in synthetic organic chemistry. This compound is valued for its unique molecular architecture, which combines a brominated benzothiophene core with a trifluoromethyl group and a methyl ester functionality, enabling precise chemical modifications. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, and insecticides with enhanced activity and selectivity.
• Material Science: Used in the research and development of organic electronic materials, such as semiconductors and light-emitting diodes (OLEDs), due to its electron-deficient thiophene structure.
• Chemical Synthesis: An essential reagent for Suzuki-Miyaura and other cross-coupling reactions, facilitating the construction of complex, functionalized heterocyclic systems.
• Fluorine Chemistry: The trifluoromethyl group makes it a valuable synthon for introducing fluorine atoms into target molecules to improve metabolic stability, lipophilicity, and bioavailability.

Basic Information

Product Name	5-Bromo-3-Trifluoromethylbenzo[B]Thiophene-2-Carboxylic Acid Methyl Ester
CAS No.	617706-20-4
Molecular Formula	C11H6BrF3O2S
Molecular Weight	339.13 g/mol
Synonyms	Methyl 5-bromo-3-(trifluoromethyl)benzo[b]thiophene-2-carboxylate; 5-Bromo-3-trifluoromethyl-1-benzothiophene-2-carboxylic acid methyl ester; 2-Benzo[b]thiophenecarboxylic acid, 5-bromo-3-(trifluoromethyl)-, methyl ester; 617706-20-4; Methyl 5-bromo-3-(trifluoromethyl)-1-benzothiophene-2-carboxylate
EINECS	Contact for details

Quality Control

Our 5-Bromo-3-Trifluoromethylbenzo[B]Thiophene-2-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP guidelines where applicable, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive (hygroscopic); ensure containers are sealed under an inert atmosphere after opening to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.