Description

4-(Bromomethyl)-4'-(Trifluoromethyl)-1,1'-Biphenyl is a high-value biphenyl derivative featuring both bromomethyl and trifluoromethyl functional groups, making it a versatile and critical synthetic intermediate. This compound is essential for constructing complex molecular architectures where precise electronic and steric properties are required. It is primarily sought after by research and development teams in the pharmaceutical and advanced materials sectors for applications in medicinal chemistry, agrochemical synthesis, and the development of organic electronic materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and plant growth regulators leveraging the trifluoromethyl group's metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for the synthesis of fluorinated biphenyl cores used in liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromomethyl group acts as a reactive handle for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create extended conjugated systems.
• Functional Material Research: Employed in academic and industrial R&D for creating novel polymers, ligands for catalysis, and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Useful for synthesizing tagged molecules or probes for studying biological processes and target engagement.

Basic Information

Product Name	4-(Bromomethyl)-4'-(Trifluoromethyl)-1,1'-Biphenyl
CAS No.	613241-14-8
Molecular Formula	C14H10BrF3
Molecular Weight	315.13 g/mol
Synonyms	4'-(Trifluoromethyl)-4-bromomethylbiphenyl; [1,1'-Biphenyl]-4-methanol, 4'-(trifluoromethyl)-, bromide; 4-(Bromomethyl)-4'-trifluoromethylbiphenyl; 4'-(Trifluoromethyl)biphenyl-4-ylmethyl bromide; 4-(Bromomethyl)-4'-(trifluoromethyl)biphenyl; (4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl bromide
EINECS	Contact for details

Quality Control

Every batch of 4-(Bromomethyl)-4'-(Trifluoromethyl)-1,1'-Biphenyl is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay (HPLC), identity (IR, NMR), and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC Area %)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.