Description

N1,N1-Diethyl-N3-(6-Methyl-5,6,7,8-Tetrahydrobenzo[4,5]Thieno[2,3-D]Pyrimidin-4-Yl)Propane-1,3-Diamine is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of targeted therapeutic agents, particularly kinase inhibitors. It is essential for research institutions and pharmaceutical manufacturers engaged in the development of novel small-molecule drugs for oncology and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potent and selective kinase inhibitors for cancer therapy.
• Drug Discovery Research: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in the final or penultimate steps of manufacturing complex active drug substances.
• Biochemical Research: Serves as a tool compound for studying specific enzyme pathways and biological mechanisms in vitro.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	N1,N1-Diethyl-N3-(6-Methyl-5,6,7,8-Tetrahydrobenzo[4,5]Thieno[2,3-D]Pyrimidin-4-Yl)Propane-1,3-Diamine
CAS No.	611197-59-2
Molecular Formula	C20H29N5S
Molecular Weight	371.55 g/mol
Synonyms	4-[[3-(Diethylamino)propyl]amino]-6-methyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine; 6-Methyl-4-[[3-(diethylamino)propyl]amino]-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine; BMS-599626 Intermediate; BMS599626 Intermediate; Kinase Inhibitor Intermediate; THTP-Diethylaminopropylamine Derivative
EINECS	Contact for details

Quality Control

Every batch of N1,N1-Diethyl-N3-(6-Methyl-5,6,7,8-Tetrahydrobenzo[4,5]Thieno[2,3-D]Pyrimidin-4-Yl)Propane-1,3-Diamine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the stringent requirements for pharmaceutical development. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.