Description

Rizatriptan-D6 is a deuterium-labeled analog of the active pharmaceutical ingredient Rizatriptan benzoate, a selective serotonin receptor agonist. This high-purity stable isotope-labeled compound is an essential reference standard and internal standard for precise quantitative analysis in bioanalytical research and pharmaceutical development. It is primarily used by analytical chemists and researchers in pharmaceutical, contract research, and academic laboratories for method development, validation, and pharmacokinetic studies. The compound's deuterium labeling provides a reliable mass shift for accurate LC-MS/MS detection, ensuring data integrity and regulatory compliance.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical component in the quantification of Rizatriptan and its metabolites in biological matrices such as plasma, serum, and urine.
• Pharmaceutical Research & Development: Used in method development and validation studies to support drug discovery, pharmacokinetic (PK), and pharmacodynamic (PD) research.
• Bioanalytical Assay Calibration: Enables the creation of accurate calibration curves for high-sensitivity mass spectrometry-based assays, improving precision and reducing matrix effects.
• Metabolite Tracing and Identification: Facilitates studies on drug metabolism and the identification of metabolic pathways due to its isotopic signature.
• Quality Control and Assurance: Employed as a certified reference material (CRM) to ensure the accuracy and reliability of analytical results in GLP and GMP environments.
• Clinical Trial Support: Essential for the robust bioanalysis required during clinical trials to measure drug concentration levels in participants.

Basic Information

Item	Detail
Product Name	Rizatriptan-D6
CAS No.	606927-07-5
Molecular Formula	C15H13D6N5
Molecular Weight	Contact for details
Synonyms	Rizatriptan (d6); 3-[2-(Dimethylamino)ethyl]-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-d6; N,N-Dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine-d6; MK-0462-d6; Maxalt-d6; Deuterated Rizatriptan; Rizatriptan Benzoate-d6 (labeled moiety)
EINECS	Contact for details

Quality Control

Our Rizatriptan-D6 is manufactured under strict quality systems to ensure the highest standards of isotopic purity and chemical integrity. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm identity, chemical purity, and isotopic enrichment. A comprehensive Certificate of Analysis (COA) is provided, detailing batch-specific results. We support compliance with ICH, FDA, and EMA guidelines for bioanalytical method validation, making this material suitable for regulated studies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.