Description

4H-Pyrrolo[3,2-D]Isoxazole,3-[2-Chloro-5-(Trifluoromethyl)Phenyl]-5,6-Dihydro-(9Ci) is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure incorporating a trifluoromethylphenyl group. This compound is of significant value for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research targeting specific biological pathways. It is primarily sought by R&D teams and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries for developing new therapeutic agents and crop protection products.

Application

• Pharmaceutical Intermediate: Key building block in the research and development of new drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead optimization due to its unique fused isoxazole-pyrrole scaffold.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced herbicides and pesticides, leveraging the biological activity of the trifluoromethyl group.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and cellular processes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production for clinical trials.
• Academic Research: Employed in university and institutional labs for heterocyclic chemistry studies and the development of novel synthetic methodologies.

Basic Information

Product Name	4H-Pyrrolo[3,2-D]Isoxazole,3-[2-Chloro-5-(Trifluoromethyl)Phenyl]-5,6-Dihydro-(9Ci)
CAS No.	603067-93-2
Molecular Formula	C13H8ClF3N2O
Molecular Weight	300.66 g/mol
Synonyms	3-[2-Chloro-5-(trifluoromethyl)phenyl]-5,6-dihydro-4H-pyrrolo[3,2-d]isoxazole; 5,6-Dihydro-3-[2-chloro-5-(trifluoromethyl)phenyl]-4H-pyrrolo[3,2-d]isoxazole; 4H-Pyrrolo[3,2-d]isoxazole, 3-[2-chloro-5-(trifluoromethyl)phenyl]-5,6-dihydro-; 603067-93-2; 3-(2-Chloro-5-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-2H-isoindole; Pyrroloisoxazole derivative CAS 603067-93-2
EINECS	Contact for details

Quality Control

Our 4H-Pyrrolo[3,2-D]Isoxazole derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to ensure traceability and compliance with your research or production requirements. We support development with custom purity grades and analytical method development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be light-sensitive (store away from light) and hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere such as nitrogen or argon for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.