Description

3-Hydroxymethyl-5-Methoxyindole-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its indole-based molecular structure. This compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting neurological and oncological pathways. It is essential for research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, where precise chemical architecture and reliable supply are paramount.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, especially those with indole or tryptamine-based pharmacophores.
• Neurological Drug Research: Used in the development of compounds targeting serotonin receptors and related neurological pathways.
• Oncology Research: Serves as a building block for novel anti-cancer agents and kinase inhibitors under investigation.
• Chemical Synthesis: Utilized in organic chemistry for the construction of complex heterocyclic systems and for introducing protected functional groups.
• Process Development: Employed in scale-up and optimization studies for API manufacturing routes within GMP environments.
• Academic & Contract Research: Supplied to universities and CROs for medicinal chemistry programs and exploratory synthesis.

Basic Information

Product Name	3-Hydroxymethyl-5-Methoxyindole-1-Carboxylic Acid tert-Butyl Ester
CAS No.	600136-09-2
Molecular Formula	C15H19NO4
Molecular Weight	277.32 g/mol
Synonyms	1H-Indole-1-carboxylic acid, 3-(hydroxymethyl)-5-methoxy-, 1,1-dimethylethyl ester; tert-Butyl 3-(hydroxymethyl)-5-methoxy-1H-indole-1-carboxylate; 5-Methoxy-3-hydroxymethylindole-1-carboxylic acid tert-butyl ester; Boc-5-Methoxy-3-hydroxymethylindole; 3-Hydroxymethyl-5-methoxyindole-1-Boc; 1-Boc-3-Hydroxymethyl-5-methoxyindole; 5-Methoxy-1H-indole-3-methanol, 1-Boc derivative
EINECS	Contact for details

Quality Control

Our 3-Hydroxymethyl-5-Methoxyindole-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content, to ensure it meets the stringent requirements for pharmaceutical R&D and process chemistry. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.