Description

(+/-)-Nicotine-Methyl-D3 CAS NO 69980-24-1 is a deuterated isotopologue of nicotine, where three hydrogen atoms on the methyl group are replaced by deuterium. This stable isotope-labeled compound is critical for ensuring accuracy and reliability in quantitative analytical methods. It is primarily utilized by analytical laboratories, research institutions, and pharmaceutical companies engaged in pharmacokinetic studies, metabolic research, and the development of high-precision testing protocols.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a crucial reference compound for the accurate quantification of nicotine and its metabolites in complex biological matrices like plasma, urine, and saliva.
• Pharmacokinetic and Metabolic Studies: Enables precise tracking of nicotine absorption, distribution, metabolism, and excretion (ADME) in clinical and preclinical research.
• Forensic and Toxicology Testing: Used in accredited laboratories for the definitive identification and measurement of nicotine levels in forensic and workplace testing scenarios.
• Biomarker Research: Facilitates the study of nicotine exposure and its correlation with biological outcomes in epidemiological and public health research.
• Method Development and Validation: Essential for developing, optimizing, and validating robust analytical methods in compliance with guidelines like FDA 21 CFR Part 11.
• Quality Control in Reference Material Production: Employed in the calibration and verification of analytical instruments and the production of certified reference materials (CRMs).

Basic Information

Item	Detail
Product Name	(+/-)-Nicotine-Methyl-D3
CAS No.	69980-24-1
Molecular Formula	C₁₀H₁₁D₃N₂
Molecular Weight	165.24 g/mol
Synonyms	Nicotine-methyl-d3; (S)-3-(1-Methyl-2-pyrrolidinyl)pyridine (methyl-d3); Nicotine (methyl-d3); DL-Nicotine-methyl-d3; 1-Methyl-2-(3-pyridyl)pyrrolidine (methyl-d3); Nicotine-d3 (methyl labeled); Nicotine Internal Standard (methyl-d3); Isotopic Nicotine Derivative
EINECS	Contact for details

Quality Control

Our (+/-)-Nicotine-Methyl-D3 is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and MS, to verify chemical purity, isotopic enrichment, and structural identity. Certificates of Analysis (COA) detailing all test results are provided to ensure full traceability and compliance with your research or quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and volatilization. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (by GC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.