Description

17α,18α-Dihydroxyyohimban-16α-Carboxylic Acid Methyl Ester is a high-purity, complex indole alkaloid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate and reference standard for the study of bioactive natural products and their analogs. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents targeting the central nervous system and other physiological pathways.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex yohimbine-related alkaloids and potential drug candidates.
• Reference Standard: Used as a high-purity analytical standard in HPLC, LC-MS, and NMR for method development, validation, and quality control of related substances.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore modifications of the yohimban core for enhanced biological activity or reduced side effects.
• Biochemical Research: Investigated for its interaction with adrenergic and serotonergic receptors in pharmacological and neurological studies.
• Process Chemistry Development: Serves as a model compound for developing and scaling up purification and isolation processes for sensitive, high-value alkaloids.

Basic Information

Product Name	17α,18α-Dihydroxyyohimban-16α-Carboxylic Acid Methyl Ester
CAS No.	69862-18-6
Molecular Formula	C21H26N2O5
Molecular Weight	386.44 g/mol
Synonyms	Methyl 17α,18α-dihydroxyyohimban-16α-carboxylate; 16α-Carbomethoxy-17α,18α-dihydroxyyohimban; Yohimban-16α-carboxylic acid, 17,18-dihydroxy-, methyl ester, (16α,17α,18α)-; 17α,18α-Dihydroxy-16α-carbomethoxyyohimban
EINECS	Contact for details

Quality Control

Our 17α,18α-Dihydroxyyohimban-16α-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing all relevant specifications to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.