Description

16-Mercaptohexadecanoic Acid is a high-purity, long-chain alkanethiol carboxylic acid that serves as a critical functionalized building block in advanced material science. Its unique bifunctional structure, featuring both a terminal thiol (-SH) and a carboxylic acid (-COOH) group, enables precise surface modification and controlled self-assembly. This compound is essential for researchers and manufacturers in nanotechnology, pharmaceuticals, and specialty polymer synthesis who require reliable, high-quality intermediates for creating functionalized surfaces and tailored molecular architectures.

Application

• Self-Assembled Monolayer (SAM) Formation: Used to create highly ordered, functionalized monolayers on gold, silver, and other metal surfaces for biosensors, corrosion inhibition, and electronic devices.
• Nanoparticle Functionalization: Acts as a stabilizing and functionalizing agent for metal nanoparticles (e.g., gold, quantum dots), imparting water solubility and providing a carboxylate handle for further bioconjugation.
• Polymer Modification & Cross-linking: Serves as a chain transfer agent or cross-linker in polymer chemistry to introduce thiol or carboxyl functionality, modifying material properties like adhesion and biocompatibility.
• Lubricant & Additive Synthesis: Employed as an intermediate in the synthesis of extreme-pressure additives and multifunctional lubricants for high-performance industrial applications.
• Pharmaceutical Intermediates: Utilized in the synthesis of prodrugs or as a linker molecule in drug delivery systems, leveraging its ability to form disulfide bonds for controlled release.
• Surface Plasmon Resonance (SPR) & Diagnostic Chips: Key component for immobilizing biomolecules on sensor chips used in label-free detection and diagnostic assays.

Basic Information

Product Name	16-Mercaptohexadecanoic Acid
CAS No.	69839-68-5
Molecular Formula	C₁₆H₃₂O₂S
Molecular Weight	288.49 g/mol
Synonyms	16-Sulfanylhexadecanoic Acid; Hexadecanoic Acid, 16-Mercapto-; 16-Thiohexadecanoic Acid; ω-Mercaptopalmitic Acid; 16-Mercaptopalmitic Acid; 16-MHA; 16-Mercaptohexadecylic Acid; 16-SHA
EINECS	Contact for details

Quality Control

Our 16-Mercaptohexadecanoic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and titration for thiol content, to ensure it meets the high standards required for research and industrial applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and conformance to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation of the thiol group. Keep the container in a cool, dry, and well-ventilated place, separate from oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Thiol Content (Titration)	≥ 96.0%
Melting Point	88 - 92 °C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.