Description

3-(Trimethylsiloxy)-5α-Androst-3-Ene is a high-purity, organosilicon-modified steroid derivative, serving as a critical advanced intermediate in organic synthesis. Its value lies in providing a protected, reactive handle for the controlled functionalization of the steroidal core, enabling the development of novel compounds. This product is essential for research and development chemists in the pharmaceutical, biotechnology, and fine chemical sectors, particularly those working on hormone analogs, drug discovery, and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel steroid-based therapeutics and hormone analogs.
• Research & Development: Used in academic and industrial R&D for exploring new chemical entities and biological pathways.
• Fine Chemical Synthesis: Intermediate in the multi-step synthesis of complex, high-value specialty chemicals and catalysts.
• Bioconjugation Chemistry: Potential use in creating steroidal probes or conjugates for biochemical and diagnostic applications.
• Process Chemistry: Serves as a standardized intermediate for scaling up the production of target steroid molecules.

Basic Information

Product Name	3-(Trimethylsiloxy)-5α-Androst-3-Ene
CAS No.	69833-86-9
Molecular Formula	C22H38OSi
Molecular Weight	346.62 g/mol
Synonyms	5α-Androst-3-en-3-ol, trimethylsilyl ether; 3-Trimethylsiloxyandrost-5-ene; Androst-5-en-3-ol, 3-trimethylsilyl ether, (5α)-; 3-TMS-androst-5-ene; 3-[(Trimethylsilyl)oxy]-5α-androst-3-ene; 3-O-Trimethylsilylandrost-5-ene; 5α-Androst-3-en-3-yl trimethylsilyl ether
EINECS	Contact for details

Quality Control

Our 3-(Trimethylsiloxy)-5α-Androst-3-Ene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical intermediates and can accommodate custom purity requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original sealed container to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.