Description

n-[2-(Trimethylammonium)Ethyl]Maleimide Chloride is a specialized, high-purity cationic maleimide derivative, a key intermediate for advanced bioconjugation and polymer modification. This compound is essential for researchers and manufacturers requiring precise, site-specific labeling of biomolecules or the creation of functional materials with cationic character. It is primarily utilized in the development of pharmaceuticals, diagnostic reagents, and specialty polymers where controlled reactivity and water solubility are critical.

Application

• Bioconjugation Reagent: For site-specific labeling of proteins, antibodies, and peptides via thiol-maleimide chemistry, particularly useful for creating cationic conjugates.
• Polymer Chemistry: As a functional monomer or crosslinker for synthesizing cationic polymers, hydrogels, and smart materials with responsive properties.
• Drug Delivery Systems: In the fabrication of drug carriers and liposome surfaces to enhance cellular uptake through positive charge interactions.
• Diagnostic Assay Development: For coupling detection molecules (e.g., enzymes, fluorophores) to probes in immunoassays and biosensors.
• Surface Modification: To introduce permanent cationic functionality onto surfaces for biomedical devices or chromatography media.
• Research & Development: As a critical building block in organic synthesis and chemical biology for exploring new therapeutic modalities.

Basic Information

Product Name	n-[2-(Trimethylammonium)Ethyl]Maleimide Chloride
CAS No.	69684-10-2
Molecular Formula	C9H15ClN2O2
Molecular Weight	218.68 g/mol
Synonyms	N-(2-Trimethylammonioethyl)maleimide chloride; (2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N,N,N-trimethylethanaminium chloride; Maleimidopropyltrimethylammonium chloride; 1-[2-(Trimethylammonio)ethyl]-1H-pyrrole-2,5-dione chloride; TMAEM-CI; Cationic Maleimide; N-(2-(N,N,N-Trimethylammonium)ethyl)maleimide chloride
EINECS	Contact for details

Quality Control

Our n-[2-(Trimethylammonium)Ethyl]Maleimide Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and production. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic (moisture-sensitive) nature, the container should be opened under a dry, inert atmosphere and resealed immediately after use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.