Description

2-Azabicyclo[2.1.0]Pentane-3-Carboxylic Acid is a specialized bicyclic amino acid derivative, serving as a crucial chiral building block and constrained scaffold in advanced organic synthesis. Its unique fused ring system imparts significant structural rigidity, making it invaluable for modulating the conformational and pharmacological properties of target molecules. This high-purity intermediate is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex natural product analogs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and metabolic disease targets.
• Constrained Peptide Mimetic: Used to introduce conformational restraint into peptide backbones, enhancing metabolic stability and receptor selectivity in peptide-based therapeutics.
• Ligand and Catalyst Development: Serves as a precursor for novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Agrochemical Synthesis: Employed in the creation of novel, biologically active compounds for crop protection products.
• Chemical Biology Probe: Utilized as a tool compound to study enzyme mechanisms and protein-ligand interactions due to its structurally defined framework.
• Material Science Research: Investigated as a monomer or additive for creating polymers with unique thermal and mechanical properties.

Basic Information

Product Name	2-Azabicyclo[2.1.0]Pentane-3-Carboxylic Acid
CAS No.	69545-66-0
Molecular Formula	C6H9NO2
Molecular Weight	127.14 g/mol
Synonyms	2-Azabicyclo[2.1.0]pentane-3-carboxylic acid; (1R,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxylic acid (related stereoisomer); 3-Carboxy-2-azabicyclo[2.1.0]pentane; Bicyclic proline analog; Constrained proline derivative; 2-Aza-bicyclo[2.1.0]pentane-3-carboxylic acid; 2-Azabicyclo[2.1.0]pentane-3-carboxylic acid, 95%
EINECS	Contact for details

Quality Control

Our 2-Azabicyclo[2.1.0]Pentane-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral assay, NMR, and MS for structural confirmation, to ensure it meets the exacting standards required for research and process development. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.