Description

n-[2-[6-(Benzyloxy)-5-Methoxyindol-3-Yl]Ethyl]Acetamide-D4 is a deuterated analog of a key indole-based intermediate, where four hydrogen atoms are replaced with deuterium, a stable isotope. This deuteration is critical for enhancing metabolic stability and traceability in pharmacokinetic and drug metabolism studies. This high-purity compound is primarily utilized by pharmaceutical R&D teams and analytical laboratories engaged in the development and validation of deuterated active pharmaceutical ingredients (APIs) and their corresponding reference standards.

Application

• Deuterated Pharmaceutical Intermediate: Serves as a stable isotope-labeled building block for synthesizing deuterated drug candidates with improved metabolic profiles.
• Internal Standard for Mass Spectrometry: Used as a quantitative internal standard in LC-MS and GC-MS analysis for accurate bioanalytical method development and validation.
• Metabolic Pathway Tracing: Enables detailed studies of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical research.
• Reference Material: Acts as a certified reference material (CRM) for quality control and regulatory compliance in API manufacturing.
• Isotope Effect Research: Facilitates investigations into kinetic isotope effects (KIE) for mechanistic studies in medicinal chemistry.

Basic Information

Product Name	n-[2-[6-(Benzyloxy)-5-Methoxyindol-3-Yl]Ethyl]Acetamide-D4
CAS No.	69533-62-6
Molecular Formula	C20H18D4N2O3
Molecular Weight	~338.42 g/mol
Synonyms	N-[2-[6-(Benzyloxy)-5-methoxy-1H-indol-3-yl]ethyl]acetamide-d4; 6-(Benzyloxy)-5-methoxytryptamine-d4 acetamide; Deuterated Benzyloxy-methoxyindole Ethylacetamide; 69533-62-6; Acetamide, N-[2-[6-(benzyloxy)-5-methoxy-1H-indol-3-yl]ethyl]-, 2,2,3,3-d4-; [D4]-N-[2-[6-(Benzyloxy)-5-methoxyindol-3-yl]ethyl]acetamide
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality management systems to ensure isotopic purity and chemical integrity. Each batch is characterized by advanced analytical techniques including NMR (¹H, ¹³C, ²H), High-Resolution Mass Spectrometry (HRMS), and HPLC to confirm deuteration level and chemical purity. Certificates of Analysis (COA) detailing isotopic enrichment (typically >98 atom % D), chemical purity, and analytical spectra are provided with every shipment to support your regulatory and research documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C to maintain optimal stability of the deuterated label.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuteration Degree (MS/NMR)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.