Description

5-Methoxy-6-(Phenylmethoxy)-1H-Indole-3-Ethan-α,α,β,β-Amine-D4 is a high-purity, deuterium-labeled chemical intermediate of significant importance in advanced research and development. This compound is specifically valued for its role as a stable isotope-labeled internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is primarily sought after by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in method development, pharmacokinetic studies, and metabolite identification for novel therapeutic agents.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of its non-deuterated counterpart or related metabolites in complex biological matrices like plasma, serum, and tissue homogenates.
• Pharmaceutical R&D: Used in drug metabolism and pharmacokinetics (DMPK) studies to track absorption, distribution, metabolism, and excretion (ADME) profiles of new chemical entities.
• Biomarker Analysis: Enables accurate measurement of endogenous or exogenous biomarkers in clinical and preclinical research settings.
• Method Development and Validation: Serves as a key component in developing robust, sensitive, and specific analytical methods compliant with regulatory guidelines (e.g., FDA, EMA).
• Isotope Dilution Mass Spectrometry (IDMS): Employed in this gold-standard technique to achieve the highest possible accuracy in quantitative analysis, minimizing matrix effects and instrument variability.

Basic Information

Product Name	5-Methoxy-6-(Phenylmethoxy)-1H-Indole-3-Ethan-α,α,β,β-Amine-D4
CAS No.	69533-60-4
Molecular Formula	C₁₈H₁₄D₄N₂O₂
Molecular Weight	~298.37 g/mol
Synonyms	5-Methoxy-6-(benzyloxy)-1H-indole-3-ethanamine-α,α,β,β-d4; 6-(Benzyloxy)-5-methoxy-1H-indole-3-ethanamine-d4; Deuterated 5-Methoxy-6-(Phenylmethoxy)indole-3-ethylamine; 5-Methoxy-6-(Phenylmethoxy)indole-3-ethylamine-d4; 5-Methoxy-6-(benzyloxy)indole-3-ethylamine-d4; 6-Benzyloxy-5-methoxyindole-3-ethylamine-d4; 5-Methoxy-6-benzyloxyindole-3-ethylamine-d4
EINECS	Contact for details

Quality Control

Every batch of 5-Methoxy-6-(Phenylmethoxy)-1H-Indole-3-Ethan-α,α,β,β-Amine-D4 is manufactured and tested under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, verified by advanced analytical techniques including NMR (¹H, ¹³C), HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic purity (D-enrichment), and identity is provided with each shipment to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C under inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.