Description

1,4-Dinitrosopiperazine-D8 is a deuterium-labeled isotopologue of 1,4-dinitrosopiperazine, a compound of significant interest in analytical and research chemistry. This stable isotope-labeled standard is essential for ensuring accuracy and reliability in quantitative mass spectrometry analyses. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, environmental, and forensic science sectors for method development, validation, and as an internal standard in trace-level detection.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative reference standard in liquid chromatography-tandem mass spectrometry for the analysis of nitrosamine impurities in pharmaceutical products.
• Metabolic Pathway Tracing: Used in deuterium-labeling studies to investigate the metabolic fate and biotransformation pathways of nitrosamine compounds in biological systems.
• Environmental Analysis: Enables precise quantification of nitrosamine derivatives in complex environmental matrices such as water and soil samples.
• Forensic Toxicology: Supports accurate identification and measurement of specific nitrosamines in forensic investigations.
• Method Development & Validation: A key tool for developing, optimizing, and validating highly sensitive analytical methods compliant with regulatory guidelines (e.g., ICH M7, FDA).
• Stable Isotope Dilution Assay (SIDA): The gold-standard technique for achieving high-precision quantification, correcting for analyte loss during sample preparation.

Basic Information

Product Name	1,4-Dinitrosopiperazine-D8
CAS No.	69340-07-4
Molecular Formula	C4D8N4O2
Molecular Weight	180.22 g/mol
Synonyms	1,4-Dinitrosopiperazine-d8; DNP-d8; Piperazine, 1,4-dinitroso-, octadeuterio-; 1,4-Dinitrosopiperazine (D8); Octadeuterio-1,4-dinitrosopiperazine; [D8]-1,4-Dinitrosopiperazine; Stable Isotope Labeled 1,4-Dinitrosopiperazine
EINECS	Contact for details

Quality Control

Our 1,4-Dinitrosopiperazine-D8 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (D-enrichment), chemical purity by HPLC, and identity confirmation. We support compliance with ICH Q3, ICH M7, and other relevant pharmaceutical impurity guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. This material is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.