Description

5Z,8Z,11Z,14Z-Eicosatetraenoic-5,6,8,9,11,12,14,15-D8 Acid is a deuterium-labeled analog of arachidonic acid, a key polyunsaturated fatty acid in mammalian biochemistry. This stable isotope-labeled compound is essential for advanced research, enabling precise metabolic tracing and quantification in complex biological systems. It is a critical tool for scientists in pharmaceutical R&D, lipidomics, and metabolic pathway analysis who require high-purity, isotopically defined standards.

Application

• Internal Standard for Mass Spectrometry: Used as a quantitative reference standard in LC-MS and GC-MS analysis of arachidonic acid and its metabolites.
• Metabolic Pathway Tracing: Enables the study of eicosanoid biosynthesis, including prostaglandins, leukotrienes, and thromboxanes, in cell culture and in vivo models.
• Pharmaceutical Research: Supports drug discovery efforts targeting inflammation, cardiovascular disease, and neurological disorders by elucidating arachidonic acid cascade mechanisms.
• Biochemical Assay Development: Serves as a calibrated substrate or standard in enzymatic assays for phospholipases, cyclooxygenases, and lipoxygenases.
• Nutritional and Lipidomics Research: Facilitates the accurate measurement of fatty acid turnover, incorporation, and flux in nutritional studies and systems biology.

Basic Information

Item	Details
Product Name	5Z,8Z,11Z,14Z-Eicosatetraenoic-5,6,8,9,11,12,14,15-D8 Acid
CAS No.	69254-37-1
Molecular Formula	C20H24D8O2
Molecular Weight	312.52 g/mol (approx.)
Synonyms	Deuterated Arachidonic Acid; Arachidonic Acid-d8; 5,6,8,9,11,12,14,15-Octadeutero-5Z,8Z,11Z,14Z-eicosatetraenoic Acid; (5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic-5,6,8,9,11,12,14,15-d8 Acid; AA-d8; [5,6,8,9,11,12,14,15-2H8]Arachidonic Acid; Eicosa-5Z,8Z,11Z,14Z-tetraenoic-5,6,8,9,11,12,14,15-D8 Acid
EINECS	Contact for details

Quality Control

Every batch of our deuterated arachidonic acid is manufactured and analyzed to meet the stringent requirements of research and analytical applications. We employ advanced techniques including NMR and high-resolution mass spectrometry to confirm isotopic enrichment and positional labeling. Certificates of Analysis (COA) are provided, detailing purity (by HPLC), isotopic purity, and chemical identity. Our quality system ensures traceability and consistency for reliable experimental results.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity	≥ 98 atom % D
Isotopic Enrichment	≥ 98% at designated positions (5,6,8,9,11,12,14,15)
Solubility	Soluble in ethanol, DMSO, and common organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.