Description

Beclomethasone 21-Propionate is a synthetic corticosteroid ester, specifically the 21-propionate derivative of beclomethasone. This compound is a key pharmaceutical intermediate and active pharmaceutical ingredient (API) of significant commercial importance in the development and manufacture of potent anti-inflammatory and immunosuppressive medications. It is primarily utilized by pharmaceutical manufacturers and research institutions in the production of inhalation therapies for respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD).

Application

• Active Pharmaceutical Ingredient (API): Primary use as the core active component in the synthesis of final dosage forms for inhalation therapy.
• Respiratory Medicine Manufacturing: Critical intermediate in the production of metered-dose inhalers (MDIs), dry powder inhalers (DPIs), and nasal sprays for asthma and allergic rhinitis treatment.
• Pharmaceutical Research & Development: Serves as a reference standard and a starting material for the development of novel corticosteroid derivatives and formulations.
• Anti-inflammatory Drug Synthesis: Used in the synthesis of topical and systemic corticosteroid medications targeting inflammatory pathways.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of generic and proprietary respiratory drugs.
• Analytical Standard: Employed as a high-purity standard in quality control (QC) and analytical method development (e.g., HPLC, GC) within pharmaceutical laboratories.

Basic Information

Product Name	Beclomethasone 21-Propionate
CAS No.	69224-79-9
Molecular Formula	C28H37ClO7
Molecular Weight	521.04 g/mol
Synonyms	Beclomethasone 17,21-Dipropionate (common name); 9-Chloro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate; Beclometasone Dipropionate (INN); BDP; Becloforte; Beclovent; Vanceril; QVAR; Clenil; Aldecin; Propaderm; (8S,9R,10S,11S,13S,14S,16S,17R)-9-Chloro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one 17-propionate
EINECS	Contact for details

Quality Control

Our Beclomethasone 21-Propionate is manufactured under strict quality management systems, targeting specifications suitable for pharmaceutical applications. Quality is assured through rigorous in-process controls and comprehensive final release testing, which may include identification, assay, related substances, residual solvents, and specific tests. We provide full traceability and support regulatory filings. Certificates of Analysis (COA) are available upon request, detailing compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to protect from moisture. For long-term storage, consider using desiccants. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.