Description

Nedocromil Sodium is a synthetic pyranoquinoline dicarboxylic acid derivative, recognized for its potent anti-inflammatory and mast cell stabilizing properties. This compound is a critical active pharmaceutical ingredient (API) valued for its efficacy in managing allergic and inflammatory respiratory conditions. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development and production of inhalation therapies.

Application

• Pharmaceutical API: Primary use as the active ingredient in metered-dose inhalers (MDIs) and nasal sprays for asthma and allergic rhinitis prophylaxis.
• Ophthalmic Solutions: Formulation component in eye drops for the treatment of allergic conjunctivitis and other ocular inflammatory conditions.
• Research & Development: Key reference standard and biochemical tool for studying mast cell degranulation, eosinophil chemotaxis, and airway hyperresponsiveness.
• Veterinary Medicine: Potential application in veterinary pharmaceuticals for managing respiratory allergies in companion animals.
• Drug Intermediate: Serves as a crucial synthetic intermediate in the preparation of more complex anti-inflammatory drug candidates.

Basic Information

Product Name	Nedocromil Sodium
CAS No.	69049-74-7
Molecular Formula	C19H15NNa2O7
Molecular Weight	415.31 g/mol
Synonyms	Nedocromil Sodium; Nedocromil; Tilade® (Brand Name); FPL 59002KP; 4H-Pyrano[3,2-g]quinoline-2,8-dicarboxylic acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-, disodium salt; Disodium 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylate
EINECS	Contact for details

Quality Control

Our Nedocromil Sodium is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications, including identification, assay, and impurity profile analysis. Certificates of Analysis (COA) confirming compliance with in-house specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to yellow-brown crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.