Description

(6-Iodobenzo[1,3]Dioxol-5-Yl)Methanol is a specialized iodinated benzodioxole derivative that serves as a valuable synthetic intermediate in advanced organic chemistry. Its core value lies in its functionalized structure, which combines a reactive iodinated aromatic system with a primary alcohol group, enabling its use in cross-coupling reactions and further derivatization. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting CNS disorders or as a precursor for radioiodination studies.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where the benzodioxole moiety can contribute to biological activity.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of advanced polymers and organic electronic materials.
• Cross-Coupling Reactions: The iodine atom makes it a suitable substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, or Buchwald-Hartwig couplings to create complex biaryl structures.
• Ligand and Catalyst Development: The alcohol functionality allows for modification into phosphine or nitrogen-based ligands used in homogeneous catalysis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological systems and enzyme mechanisms.

Basic Information

Product Name	(6-Iodobenzo[1,3]Dioxol-5-Yl)Methanol
CAS No.	69048-76-6
Molecular Formula	C8H7IO3
Molecular Weight	278.05 g/mol
Synonyms	5-(Hydroxymethyl)-6-iodo-1,3-benzodioxole; 6-Iodo-1,3-benzodioxole-5-methanol; 6-Iodopiperonyl alcohol; (6-Iodo-1,3-benzodioxol-5-yl)methanol; 5-Iodopiperonyl alcohol; 6-Iodo-5-(hydroxymethyl)-1,3-benzodioxole; Iodopiperonyl alcohol
EINECS	Contact for details

Quality Control

Our (6-Iodobenzo[1,3]Dioxol-5-Yl)Methanol is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and NMR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.