Description

Folic Acid-D2 CAS NO 69022-87-3 is a stable isotope-labeled analog of folic acid, where two hydrogen atoms are replaced by deuterium. This compound is essential for advanced research and development, providing a critical tool for precise metabolic and pharmacokinetic studies. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of diagnostic standards and reagents.

Application

• Internal Standard for Mass Spectrometry: Used as a quantitative reference standard in LC-MS/MS and GC-MS analysis of folic acid and its metabolites in biological matrices.
• Pharmacokinetic and Drug Metabolism Studies (DMPK): Enables accurate tracking and quantification of folic acid absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Stable Isotope Labeling in Nutritional Research: Facilitates the study of folate bioavailability, bioequivalence, and human metabolism under controlled conditions.
• Diagnostic Assay Development: Serves as a key component in calibrating and validating high-sensitivity clinical diagnostic tests for folate status.
• Biochemical Pathway Tracing: Acts as a tracer to elucidate specific biochemical pathways and enzymatic mechanisms involving folate-dependent one-carbon metabolism.
• Quality Control Reference Material: Employed in pharmaceutical quality control laboratories to ensure the accuracy and precision of analytical methods for folic acid-containing products.

Basic Information

Product Name	Folic Acid-D2
CAS No.	69022-87-3
Molecular Formula	C19H17D2N7O6
Molecular Weight	443.41 g/mol (approximate)
Synonyms	Deuterated Folic Acid; Folic Acid (Pteroyl-D2-L-glutamic acid); (2S)-2-[[4-[[(2-Amino-4-oxo-1H-pteridin-6-yl)methyl-d2]amino]benzoyl]amino]pentanedioic acid; Vitamin B9-D2; Pteroylmonoglutamic Acid-D2; Folate-D2; N-[4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl-d2]amino]benzoyl]-L-glutamic Acid
EINECS	Contact for details

Quality Control

Our Folic Acid-D2 is manufactured under strict quality control protocols to ensure high isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment, chemical purity (by HPLC), and identification. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment	≥ 98 atom % D
Assay (HPLC)	≥ 95%
Chemical Purity	≥ 98%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.