Description

1-Cyano-2-Ethoxycarbonyl-6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline is a sophisticated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex pharmaceutical molecules, particularly those targeting neurological and cardiovascular pathways. It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of novel isoquinoline-based alkaloids and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates, especially those with isoquinoline or tetrahydroisoquinoline scaffolds.
• Alkaloid Synthesis: Used in the construction of complex natural product analogs and synthetic alkaloids for biological screening and medicinal chemistry research.
• Chemical Research & Development: Serves as a versatile building block for exploring new chemical spaces and developing novel heterocyclic compounds in academic and industrial R&D labs.
• API Development: Employed in the process development and scale-up stages for new Active Pharmaceutical Ingredients, contributing to route scouting and optimization.

Basic Information

Product Name	1-Cyano-2-Ethoxycarbonyl-6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline
CAS No.	68881-59-4
Molecular Formula	C₁₅H₁₈N₂O₄
Molecular Weight	290.32 g/mol
Synonyms	Ethyl 1-cyano-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate; 2-Carbethoxy-1-cyano-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline; 1-Cyano-2-ethoxycarbonyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline; 6,7-Dimethoxy-1-cyano-3,4-dihydro-2(1H)-isoquinolinecarboxylic Acid Ethyl Ester; 1-Cyano-2-ethoxycarbonyl-6,7-dimethoxytetrahydroisoquinoline; Tetrahydroisoquinoline Derivative CAS 68881-59-4
EINECS	Contact for details

Quality Control

Our 1-Cyano-2-Ethoxycarbonyl-6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.