Description

Adenosine, 5'-[[(3S)-3-Amino-3-Carboxypropyl]Methyl-D3-Sulfonio]-5'-Deoxy-, Inner Salt is a deuterated sulfonium analog of S-adenosylmethionine (SAM), a critical biological methyl donor. This stable isotope-labeled compound is essential for advanced research in enzymology, metabolic pathway tracing, and quantitative mass spectrometry. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and contract research organizations (CROs) focused on epigenetics, metabolomics, and drug discovery.

Application

• Biochemical Research & Enzymology: Used as a deuterium-labeled cofactor or substrate in studies of methyltransferase enzymes and transmethylation reactions.
• Metabolomics & Stable Isotope Tracing: Serves as an internal standard or tracer in LC-MS/MS and GC-MS analyses for the accurate quantification of SAM and related metabolites in biological samples.
• Pharmaceutical Development: Employed in the research and development of novel therapeutics targeting epigenetic regulation and metabolic disorders.
• Diagnostic Assay Development: Utilized in the formulation of calibrators and controls for clinical diagnostic kits measuring methylation status or metabolic function.
• Isotope-Labeled Standard Production: Acts as a key intermediate or reference material for the synthesis of other labeled compounds in specialized fine chemical manufacturing.

Basic Information

Product Name	Adenosine, 5'-[[(3S)-3-Amino-3-Carboxypropyl]Methyl-D3-Sulfonio]-5'-Deoxy-, Inner Salt
CAS No.	68684-40-2
Molecular Formula	C15H23D3N6O5S
Molecular Weight	405.46 g/mol
Synonyms	5'-Deoxy-5'-[((3S)-3-amino-3-carboxypropyl)methyl-d3-sulfonio]adenosine, inner salt; Deuterated S-Adenosylmethionine (d3-SAM); S-Adenosyl-L-methionine-d3; SAM-d3; AdoMet-d3; (3S)-5'-[(3-Amino-3-carboxypropyl)methyl-d3-sulfonio]-5'-deoxyadenosine; L-S-Adenosylmethionine-d3; 68684-40-2
EINECS	Contact for details

Quality Control

Our deuterated biochemicals are produced under strict quality control protocols to ensure high isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is characterized by NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) are provided, detailing assay, isotopic enrichment (D3), and purity specifications. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 95.0%
Isotopic Enrichment (D3)	≥ 98 atom % D
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.