Description

Pentamorphone is a synthetic opioid analgesic compound of significant interest in pharmaceutical research and development. Its primary value lies in its potent pharmacological activity, making it a key subject for studies into pain management and receptor interaction. This compound is essential for researchers and developers in the pharmaceutical industry, particularly those focused on central nervous system (CNS) drug discovery, neuropharmacology, and the synthesis of novel therapeutic agents. Pentamorphone CAS NO 68616-83-1 serves as a critical reference standard and building block for advancing medicinal chemistry.

Application

• Pharmaceutical Reference Standard: Used as a high-purity analytical standard for quality control and method validation in drug testing laboratories.
• Medicinal Chemistry Research: Serves as a key intermediate or target molecule in the synthesis and study of novel opioid receptor agonists and antagonists.
• Neuropharmacology Studies: Employed in preclinical research to investigate mechanisms of pain modulation, receptor binding affinity, and signal transduction pathways.
• Biochemical Assay Development: Utilized in the development and calibration of in vitro assays for screening potential analgesic compounds.
• Academic Research: Provides a tool for universities and research institutions studying the structure-activity relationships (SAR) of opioid compounds.
• Controlled Substance Analysis: Acts as a calibrant or control in forensic and toxicology laboratories for the identification of synthetic opioids.

Basic Information

Product Name	Pentamorphone
CAS No.	68616-83-1
Molecular Formula	C₂₄H₃₁NO₄
Molecular Weight	397.51 g/mol
Synonyms	NIH 10636; 1-[(5α,6α)-4,5-Epoxy-3,14-dihydroxy-17-(2-methylbutyl)morphinan-6-yl]pyrrolidin-2-one; 6-(2-Oxopyrrolidin-1-yl)-6-desoxy-17-(2-methylbutyl)dihydrothebaine; 17-(2-Methylbutyl)dihydrothebaine-6-spiro-2'-pyrrolidone
EINECS	Contact for details

Quality Control

Our Pentamorphone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant Good Manufacturing Practice (GMP) principles for active pharmaceutical ingredients (APIs) and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.