Description

Methyl 4,5,6,7-Tetrahydro-1-(Pyridin-2-Yl)-1H-Indazole-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant commercial interest. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic scaffolds. It is primarily sought by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• Process Chemistry Development: Serves as a standard or starting material for optimizing scalable synthetic routes in API manufacturing.
• Contract Manufacturing: Supplied to CDMOs for the production of clinical trial materials and commercial APIs under GMP guidelines.
• Chemical Reference Standard: Utilized in analytical laboratories for method development, validation, and quality control of related substances.

Basic Information

Product Name	Methyl 4,5,6,7-Tetrahydro-1-(Pyridin-2-Yl)-1H-Indazole-5-Carboxylate
CAS No.	68587-29-1
Molecular Formula	C14H15N3O2
Molecular Weight	257.29 g/mol
Synonyms	Methyl 1-(2-pyridinyl)-4,5,6,7-tetrahydro-1H-indazole-5-carboxylate; 1-(Pyridin-2-yl)-4,5,6,7-tetrahydro-1H-indazole-5-carboxylic acid methyl ester; 5-Carbomethoxy-1-(2-pyridyl)-4,5,6,7-tetrahydroindazole; 68587-29-1; Methyl 1-(2-pyridyl)-4,5,6,7-tetrahydroindazole-5-carboxylate
EINECS	Contact for details

Quality Control

Our production of Methyl 4,5,6,7-Tetrahydro-1-(Pyridin-2-Yl)-1H-Indazole-5-Carboxylate adheres to stringent quality management systems to ensure batch-to-batch consistency and purity suitable for pharmaceutical research. All materials are fully characterized using advanced analytical techniques including HPLC, GC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.