Description

4-(Acetylamino)Phenyl 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indole-3-Acetate is a high-purity, non-steroidal anti-inflammatory drug (NSAID) derivative with significant research and development value. This compound is critical for pharmaceutical R&D, serving as a key intermediate in the synthesis of novel therapeutic agents targeting inflammation and pain. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic research institutions focused on developing next-generation NSAIDs and exploring new chemical entities.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced non-steroidal anti-inflammatory drugs (NSAIDs) and their prodrugs.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new anti-inflammatory compounds.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis (HPLC, LC-MS).
• Biochemical Research: Employed in in-vitro and ex-vivo studies to investigate cyclooxygenase (COX) enzyme inhibition pathways and mechanisms of action.
• Preclinical Studies: Utilized in the formulation of test articles for pharmacokinetic, pharmacodynamic, and toxicology evaluations.

Basic Information

Product Name	4-(Acetylamino)Phenyl 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indole-3-Acetate
CAS No.	68483-33-0
Molecular Formula	C27H23ClN2O5
Molecular Weight	490.94 g/mol
Synonyms	4'-Acetamidophenyl 1-(4-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetate; Amfenac Phenyl Ester; 4-Acetamidophenyl 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate; 4-Acetaminophenyl Amfenac Ester; 1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetic acid 4-acetamidophenyl ester; Amfenac 4-Acetamidophenyl Ester; [1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid 4-acetamidophenyl ester
EINECS	Contact for details

Quality Control

Our 4-(Acetylamino)Phenyl 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indole-3-Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.