Description

Bicyclo[2.2.1]Hept-5-Ene-2-Carboxylic Acid, Methyl Ester, (1S,2S,4S)- (9Ci) is a high-purity, stereochemically defined chiral building block essential for advanced organic synthesis. This compound is valued for its rigid norbornene framework and functional handles, enabling precise molecular construction in complex chemical environments. It is primarily sought by research institutions and industrial R&D teams in the pharmaceutical, agrochemical, and specialty materials sectors for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where its stereochemistry can influence biological activity and selectivity.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Polymer Science & Material Research: Acts as a monomer or co-monomer in the development of specialty polymers with unique thermal or mechanical properties, such as polycyclic olefin copolymers (COC).
• Academic & Industrial R&D: A valuable tool for methodological studies in organic chemistry, including Diels-Alder reactions and other cycloaddition transformations.
• Fine Chemical Production: Employed in the multi-step synthesis of high-value, low-volume specialty chemicals and flavors & fragrances.

Basic Information

Item	Detail
Product Name	Bicyclo[2.2.1]Hept-5-Ene-2-Carboxylic Acid, Methyl Ester, (1S,2S,4S)- (9Ci)
CAS No.	68069-49-8
Molecular Formula	C10H14O2
Molecular Weight	166.22 g/mol
Synonyms	(1S,2S,4S)-Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid methyl ester; (-)-exo-5-Norbornene-2-carboxylic acid methyl ester; Methyl (1S,2S,4S)-bicyclo[2.2.1]hept-5-ene-2-carboxylate; exo-(-)-Methyl 5-norbornene-2-carboxylate; (1S,2S,4S)-exo-Methyl 5-norbornene-2-carboxylate; Methyl exo-(-)-5-norbornene-2-carboxylate; (1S,2S,4S)-1,7,7-Trimethylbicyclo[2.2.1]hept-5-ene-2-carboxylic acid methyl ester (related structure).
EINECS	Contact for details

Quality Control

Our production of Bicyclo[2.2.1]Hept-5-Ene-2-Carboxylic Acid, Methyl Ester, (1S,2S,4S)- (9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. All materials undergo comprehensive analytical testing, including chiral HPLC, GC, NMR, and optical rotation measurement. A Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with each shipment, supporting compliance with cGMP and ISO 9001 standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product should be kept under an inert atmosphere for long-term storage to maintain stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (enantiomeric excess)
Optical Rotation [α]	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.