Description

Benzenemethanol, -α--(1-Aminocyclopropyl)- is a specialized chiral building block featuring a unique cyclopropylamine-substituted benzyl alcohol structure. This compound matters as a high-value intermediate for the synthesis of complex molecules, particularly in pharmaceutical research where its rigid, three-membered ring system can impart specific biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active ingredients and exploring new chemical spaces.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and insecticides, leveraging the conformational restraint of the cyclopropyl group.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Peptidomimetics & Bioisosteres: The 1-aminocyclopropane moiety is a valuable bioisostere in medicinal chemistry for modifying peptide backbones and improving drug-like properties.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis for constructing complex natural products and specialty chemicals.

Basic Information

Product Name	Benzenemethanol, -α--(1-Aminocyclopropyl)-
CAS No.	67997-54-0
Molecular Formula	C10H13NO
Molecular Weight	163.22 g/mol
Synonyms	α-(1-Aminocyclopropyl)benzyl Alcohol; (1-Aminocyclopropyl)(phenyl)methanol; 1-Amino-1-(hydroxymethyl)cyclopropane; Benzyl alcohol, α-(1-aminocyclopropyl)-; (1-Aminocyclopropyl)phenylmethanol; (α-Hydroxybenzyl)cyclopropylamine; 1-(Hydroxyphenylmethyl)cyclopropanamine
EINECS	Contact for details

Quality Control

Our Benzenemethanol, -α--(1-Aminocyclopropyl)- is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment, to ensure it meets the stringent requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.