Description

Bicyclo[1.1.1]Pentan-2-Amine is a highly strained, rigid bicyclic amine building block of significant interest in modern organic synthesis and medicinal chemistry. Its unique three-dimensional [1.1.1]propellane-derived structure enables the synthesis of novel, sterically constrained molecules with potential for enhanced biological activity and material properties. This compound is particularly valuable for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate a rigid, linear bridgehead amine moiety into their target molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in fragment-based drug discovery and for creating bioisosteres of linear chains.
• Agrochemical Synthesis: Used in the development of new pesticides and herbicides where a rigid, three-dimensional structure can improve binding specificity and environmental stability.
• Advanced Material Precursor: Serves as a monomer or cross-linking agent in the production of polymers with unique mechanical or thermal properties due to its strained cage-like geometry.
• Ligand and Catalyst Development: Employed to create novel, sterically demanding ligands for asymmetric catalysis and organometallic chemistry.
• Chemical Biology Probe: Utilized to synthesize molecular probes for studying protein-ligand interactions and enzyme mechanisms, leveraging its distinct spatial profile.
• Academic and R&D: Fundamental research in synthetic methodology development, exploring the reactivity of strained bridgehead amines.

Basic Information

Product Name	Bicyclo[1.1.1]Pentan-2-Amine
CAS No.	67947-39-1
Molecular Formula	C5H9N
Molecular Weight	83.13 g/mol
Synonyms	1-Aminobicyclo[1.1.1]pentane; [1.1.1]Propellane-2-amine; Bicyclo[1.1.1]pentan-2-ylamine; 2-Aminobicyclo[1.1.1]pentane; BCP-NH2; 1-Aza-3-bicyclo[1.1.1]pentane; 2-Aza[1.1.1]propellane
EINECS	Contact for details

Quality Control

Our Bicyclo[1.1.1]Pentan-2-Amine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We employ advanced analytical techniques including GC, HPLC, and NMR to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.