Description

4-Aminobutyric-2,2-D2 Acid CAS NO 67910-98-9 is a deuterium-labeled analog of the essential neurotransmitter γ-aminobutyric acid (GABA), where two hydrogen atoms at the 2-position are replaced with stable deuterium isotopes. This isotopic labeling is critical for creating internal standards in mass spectrometry, enabling highly accurate quantitative analysis in complex biological matrices. This compound is primarily utilized by research institutions, pharmaceutical developers, and CROs (Contract Research Organizations) engaged in advanced neurochemical research, drug metabolism and pharmacokinetics (DMPK) studies, and biomarker discovery.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering internal standard for the precise quantification of endogenous GABA levels in bioanalytical assays, enhancing data accuracy and reproducibility.
• Neuropharmacology Research: Used in tracer studies to investigate GABAergic neurotransmission, receptor binding, and the metabolism of GABA in the central nervous system.
• Drug Discovery & Development: Essential in DMPK studies for tracking the absorption, distribution, metabolism, and excretion (ADME) of new chemical entities targeting the GABA system.
• Clinical Diagnostics: Supports the development of robust diagnostic assays for neurological disorders, such as epilepsy, anxiety, and sleep disorders, where GABA pathway dysregulation is implicated.
• Metabolomics & Biomarker Research: Enables accurate profiling of GABA and related metabolites in large-scale metabolomic studies aimed at discovering novel disease biomarkers.
• Stable Isotope Labeling: Acts as a building block for the synthesis of more complex deuterated molecules used in various spectroscopic and mechanistic studies.

Basic Information

Product Name	4-Aminobutyric-2,2-D2 Acid
CAS No.	67910-98-9
Molecular Formula	C4H7D2NO2
Molecular Weight	105.13 g/mol
Synonyms	GABA-2,2-D2; 4-Amino-D2-butyric Acid; (2,2-Dideuterio-4-aminobutanoic Acid); γ-Aminobutyric-2,2-D2 Acid; 4-Amino[2,2-D2]butyric Acid; Deuterated GABA; GABA-d2; Piperidinic-2,2-D2 Acid
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced and controlled under a strict quality management system to ensure the highest isotopic and chemical purity for research applications. Each batch of 4-Aminobutyric-2,2-D2 Acid is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D%), chemical purity, and analytical method validation. We support compliance with relevant guidelines for analytical reference standards. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.