Description

L-Methionine-D4 is a stable isotope-labeled analog of the essential amino acid L-Methionine, where four hydrogen atoms are replaced by deuterium. This high-purity compound is critical for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is indispensable for researchers and quality control laboratories in the pharmaceutical, nutritional science, and metabolomics fields who require definitive results in method development and validation.

Application

• Quantitative Mass Spectrometry (MS/MS, LC-MS, GC-MS): Serves as a crucial internal standard for the precise quantification of endogenous methionine and related metabolites in complex biological matrices.
• Pharmaceutical Research & Drug Metabolism Studies (DMPK): Used in pharmacokinetic and pharmacodynamic studies to track drug absorption, distribution, metabolism, and excretion with high specificity.
• Clinical Diagnostics & Biomarker Discovery: Enables accurate measurement of methionine levels in plasma, serum, or tissue samples for research into metabolic disorders and disease states.
• Nutritional Science and Stable Isotope Tracer Studies: Acts as a tracer to investigate protein synthesis, turnover, and amino acid metabolism in vivo.
• Quality Control & Method Validation: Provides a reference standard for validating analytical methods in compliance with GLP and GMP guidelines in pharmaceutical and supplement manufacturing.
• Proteomics and Metabolomics Research: Facilitates relative and absolute quantification in large-scale profiling studies of proteins and small molecule metabolites.

Basic Information

Product Name	L-Methionine-D4
CAS No.	67866-75-5
Molecular Formula	C5H7D4NO2S
Molecular Weight	153.23 g/mol (for deuterated form)
Synonyms	(2S)-2-Amino-4-(methyl-d3-sulfanyl)butanoic-3,3,4,4-d4 acid; L-2-Amino-4-(methylthio)butyric-3,3,4,4-d4 acid; Deuterated L-Methionine; Methionine-d4; [3,3,4,4-2H4]-L-Methionine; (S)-2-Amino-4-(methylsulfanyl)butanoic-3,3,4,4-d4 acid; L-Methionine (methyl-d3, 3,3,4,4-d4)
EINECS	Contact for details

Quality Control

Our L-Methionine-D4 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (atom % D), chemical purity (by HPLC), chiral purity, and residual solvent content. We adhere to standards suitable for research and diagnostic use, with the capability to supply material traceable to recognized reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Optical Rotation	[α]20/D: Specific range provided on COA
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.