Description

(2S)-3-(1H-Indol-3-Yl)-2-[(4-Methylphenyl)Sulfonylamino]Propionic Acid is a high-purity, non-natural amino acid derivative featuring a tosyl-protected amine and an indole side chain, making it a sophisticated chiral building block for advanced synthesis. This compound is critical for researchers and manufacturers requiring precise stereochemistry and functional group compatibility in complex molecule construction. It is primarily utilized in the pharmaceutical research and development sector, particularly for the synthesis of peptide mimetics, protease inhibitors, and other biologically active compounds where the indole moiety and specific stereocenter are essential for activity.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new drug candidates, especially those targeting neurological and oncological pathways.
• Peptidomimetics & Protease Inhibitors: Used in the design and synthesis of peptide-like molecules and enzyme inhibitors, leveraging its indole and sulfonamide functional groups for targeted binding.
• Chemical Biology & Bioconjugation: Acts as a specialized building block for creating chemical probes, labeled peptides, or modified biomolecules to study protein interactions and functions.
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric reactions to introduce complex chiral centers into larger molecular architectures.
• Academic & Institutional Research: Provides a valuable tool for synthetic organic chemistry research in universities and R&D institutes focused on methodology development and novel compound libraries.

Basic Information

Product Name	(2S)-3-(1H-Indol-3-Yl)-2-[(4-Methylphenyl)Sulfonylamino]Propionic Acid
CAS No.	67850-42-4
Molecular Formula	C18H18N2O4S
Molecular Weight	358.41 g/mol
Synonyms	N-[(4-Methylphenyl)sulfonyl]-L-tryptophan; L-Tryptophan, N-[(4-methylphenyl)sulfonyl]-; N-Tosyl-L-tryptophan; (S)-2-(4-Methylphenylsulfonamido)-3-(1H-indol-3-yl)propanoic acid; N-p-Tosyl-L-tryptophan; 2-[[(4-Methylphenyl)sulfonyl]amino]-3-(1H-indol-3-yl)propanoic acid, (2S)-; Tryptophan derivative, N-tosyl-
EINECS	Contact for details

Quality Control

Our (2S)-3-(1H-Indol-3-Yl)-2-[(4-Methylphenyl)Sulfonylamino]Propionic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is stable under these conditions but should be kept in a desiccator or under an inert atmosphere if long-term storage is required, due to its sensitivity to strong acids and organic solvents as indicated in its chemical properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.