Description

(-)-Isopinocamphenylborane Tmeda Complex is a highly versatile and stereochemically defined organoboron reagent, specifically the TMEDA-stabilized complex of the chiral borane derived from (-)-α-pinene. Its primary value lies in its role as a powerful chiral hydroborating agent, enabling the highly enantioselective synthesis of secondary alcohols and other valuable intermediates. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereocontrol in their synthetic routes. The CAS number for this compound is provided in the table below.

Application

• Asymmetric Hydroboration: Key reagent for the enantioselective hydroboration of prochiral alkenes, a fundamental transformation in chiral synthesis.
• Pharmaceutical Intermediate Synthesis: Production of chiral building blocks and active pharmaceutical ingredients (APIs) requiring high enantiomeric purity.
• Agrochemical Research: Synthesis of chiral ligands and biologically active molecules for crop protection agents.
• Chiral Auxiliary and Ligand Preparation: Used in the development of new chiral catalysts and auxiliaries for asymmetric catalysis.
• Fine Chemical Manufacturing: Enantioselective synthesis of specialty chemicals, flavors, and fragrances.
• Academic and R&D Laboratories: A critical tool for methodological development in organic and organometallic chemistry.

Basic Information

Product Name	(-)-Isopinocamphenylborane Tmeda Complex
CAS No.	67826-92-0
Molecular Formula	C₁₇H₃₃BN₂
Molecular Weight	276.27 g/mol
Synonyms	(-)-IpcBH2.TMEDA; (-)-Isopinocampheylborane-TMEDA Complex; (1R)-(-)-Isopinocamphenylborane N,N,N',N'-Tetramethylethylenediamine Complex; (1R,2S,5R)-(-)-Isopinocamphenylborane TMEDA Adduct; (-)-α-Pinene Derived Borane-TMEDA Complex; IpcBH2-TMEDA; Borane, (1,7,7-trimethyl-3-bicyclo[2.2.1]heptanyl)-, compd. with N,N,N',N'-tetramethylethylenediamine (1:1); Chiral Hydroboration Reagent TMEDA Complex
EINECS	Contact for details

Quality Control

Our (-)-Isopinocamphenylborane Tmeda Complex is manufactured under strict quality protocols to ensure batch-to-batch consistency and high chemical purity, critical for reproducible enantioselectivity. Each lot is characterized by NMR spectroscopy to confirm structure and enantiomeric excess, with purity typically determined by titration. A comprehensive Certificate of Analysis (COA) detailing specific analytical results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive) and should be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (NMR)	Conforms to structure
Purity (Titration)	≥ 95.0%
Enantiomeric Purity	≥ 98.0% ee
Solubility	Soluble in common organic solvents (e.g., THF, toluene, hexanes)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.