Description

(-)-3-Methoxy Butorphanol 6-Ethylene Ketal is a high-purity, specialized chemical intermediate of significant interest in advanced pharmaceutical synthesis. This compound matters for its role as a key chiral building block in the development of complex therapeutic agents, particularly within the opioid receptor modulator class. Pharmaceutical R&D laboratories and fine chemical manufacturers need this precise intermediate to ensure the stereochemical integrity and efficacy of their final active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of novel opioid analgesics and receptor modulators.
• Research & Development: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in API manufacturing.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for target molecules in clinical development.
• Asymmetric Synthesis: Utilized in reactions requiring specific stereochemistry due to its defined chiral centers.

Basic Information

Product Name	(-)-3-Methoxy Butorphanol 6-Ethylene Ketal
CAS No.	67753-31-5
Molecular Formula	C23H33NO4
Molecular Weight	387.52 g/mol
Synonyms	(-)-3-Methoxybutorphanol 6-Ethylene Ketal; Butorphanol 6-Ketal, 3-Methoxy-; 6,14-Ethenomorphinan-3-methanol, 17-(cyclobutylmethyl)-6,7,8,14-tetrahydro-4,5α-epoxy-3-methoxy-, 6,7-ketal with ethylene glycol, (-)-; (5α,6β,14β)-17-(Cyclobutylmethyl)-6,7-[(1,2-ethanediyl)bis(oxy)]-4,5-epoxy-3-methoxy-6,7,8,14-tetrahydro-6,14-ethenomorphinan-3-methanol; 67753-31-5; (-)-3-Methoxybutorphanol ethylene ketal
EINECS	Contact for details

Quality Control

Our (-)-3-Methoxy Butorphanol 6-Ethylene Ketal is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D and synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.