Description

2-(Boc-Amino)Ethanethiol CAS NO 67385-09-5 is a protected thiol derivative featuring a tert-butoxycarbonyl (Boc) group, serving as a crucial building block in organic synthesis. Its primary value lies in providing a masked thiol functionality that is stable under a wide range of reaction conditions, allowing for selective deprotection and subsequent conjugation. This compound is essential for researchers and manufacturers in the pharmaceutical and bioconjugation sectors who require precise and controlled introduction of thiol groups into complex molecules, such as peptides, proteins, and drug-linker constructs.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and prodrugs that require thiol-mediated activity or conjugation.
• Peptide Modification: Used for the site-specific introduction of protected thiol groups into peptide chains for subsequent labeling, cyclization, or PEGylation.
• Bioconjugation Reagent: Enables the controlled attachment of drugs, fluorescent dyes, or other payloads to antibodies, proteins, or nanoparticles via thiol-maleimide or disulfide chemistry.
• Linker Chemistry: Serves as a component in the synthesis of cleavable linkers for antibody-drug conjugates (ADCs) and other targeted therapeutics.
• Material Science: Utilized in the surface functionalization of polymers and materials to introduce thiol handles for further chemical modification.
• Chemical Biology Probes: Acts as a precursor for synthesizing probes that study thiol-related biological processes and enzyme activity.

Basic Information

Product Name	2-(Boc-Amino)Ethanethiol
CAS No.	67385-09-5
Molecular Formula	C7H15NO2S
Molecular Weight	177.26 g/mol
Synonyms	2-[(tert-Butoxycarbonyl)amino]ethanethiol; N-(2-Mercaptoethyl)carbamic Acid tert-Butyl Ester; tert-Butyl N-(2-Mercaptoethyl)carbamate; Boc-Cysteamine; Boc-AETA; 2-Aminoethanethiol, N-Boc-protected; N-Boc-2-aminoethanethiol; 2-(tert-Butoxycarbonylamino)ethanethiol
EINECS	Contact for details

Quality Control

Our 2-(Boc-Amino)Ethanethiol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and cGMP manufacturing. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and prolong shelf life. Keep the container in a cool, dry, and well-ventilated area, separate from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.