Description

(S,S)-Formoterol CAS NO 67346-48-9 is a high-purity, stereochemically defined enantiomer of the potent long-acting β2-adrenergic receptor agonist (LABA) formoterol. This specific isomer is of critical importance for advanced pharmaceutical research and development, particularly in the study of receptor selectivity and the creation of novel therapeutic agents. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require precise, well-characterized compounds for drug discovery, analytical reference standards, and process development.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for the identification, assay, and impurity profiling of formoterol-based drug substances and products in compliance with pharmacopeial methods (USP, EP).
• Active Pharmaceutical Ingredient (API) Intermediate: Used in the sophisticated synthesis and development of enantiomerically pure respiratory therapeutics targeting asthma and chronic obstructive pulmonary disease (COPD).
• Biochemical Research: Employed in preclinical studies to investigate the pharmacological profile, metabolic pathways, and receptor binding kinetics specific to the (S,S)-enantiomer.
• Analytical Method Development: A key component for developing and validating sensitive chromatographic methods (e.g., Chiral HPLC) to separate and quantify formoterol enantiomers.
• Formulation Studies: Utilized in R&D for designing and testing novel drug delivery systems, such as dry powder inhalers (DPIs) and metered-dose inhalers (MDIs).
• Regulatory Submissions: Provides essential data and characterization for regulatory filings (e.g., with the FDA, EMA) requiring detailed stereochemical information of the API.

Basic Information

Product Name	(S,S)-Formoterol
CAS No.	67346-48-9
Molecular Formula	C19H24N2O4
Molecular Weight	344.41 g/mol
Synonyms	(R,R)-Formoterol; (R*,R*)-(±)-Formoterol; (±)-Formoterol; 2-Hydroxy-5-[(1RS)-1-hydroxy-2-[[(1RS)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]formanilide; Eformoterol; Foradil; Oxis; Atock; Arformoterol (related isomer); (R,R)-enantiomer of Formoterol; N-[2-Hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide
EINECS	Contact for details

Quality Control

Our (S,S)-Formoterol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and strength, typically exceeding 98.0% by HPLC. Testing includes chiral purity determination, residual solvent analysis, and control of related substances. A detailed Certificate of Analysis (COA) documenting compliance with customer specifications or in-house standards is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (S,S)-enantiomer
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0% w/w
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.