Description

2-[(tert-Butoxycarbonyl)Amino]-3-(5-Fluoro-1H-Indol-3-Yl)Propanoic Acid CAS NO 67337-05-7 is a protected amino acid derivative featuring a Boc-protected amine and a 5-fluoroindole side chain, serving as a critical synthetic intermediate. Its primary value lies in enabling the controlled synthesis of complex peptides and peptidomimetics, particularly those requiring the incorporation of a fluorinated tryptophan analog. This compound is essential for researchers and manufacturers in pharmaceutical development, specifically for creating novel drug candidates in oncology, neurology, and other therapeutic areas where fluorinated bioactive molecules are investigated.

Application

• Pharmaceutical Intermediate: Key building block for the solid-phase and solution-phase synthesis of fluorinated peptides and peptidomimetics.
• Protease Inhibitor Development: Used in research to create inhibitors targeting specific enzymes, leveraging the fluorinated indole moiety for enhanced binding affinity and metabolic stability.
• Fluorinated Tryptophan Analog Synthesis: Serves as a precursor for introducing 5-fluorotryptophan into proteins and peptides for structural biology studies (e.g., NMR spectroscopy) and biophysical research.
• Anticancer & Neuropharmacology Research: Employed in the discovery and development of novel drug candidates targeting cancer cells and neurological disorders.
• Chemical Biology Probes: Utilized to synthesize activity-based probes and labeled compounds for studying biological pathways and protein function.
• Process Chemistry & Scale-up: Suitable for GMP-compliant manufacturing processes to produce Active Pharmaceutical Ingredients (APIs) for clinical trials.

Basic Information

Product Name	2-[(tert-Butoxycarbonyl)Amino]-3-(5-Fluoro-1H-Indol-3-Yl)Propanoic Acid
CAS No.	67337-05-7
Molecular Formula	C₁₆H₁₉FN₂O₄
Molecular Weight	322.34 g/mol
Synonyms	Boc-5-F-DL-Trp-OH; N-Boc-5-fluoro-DL-tryptophan; N-(tert-Butoxycarbonyl)-5-fluoro-DL-tryptophan; 2-[(tert-Butoxycarbonyl)amino]-3-(5-fluoro-1H-indol-3-yl)propanoic acid; 5-Fluoro-N-Boc-DL-tryptophan; Boc-5-F-Trp-OH; (RS)-2-[(tert-Butoxycarbonyl)amino]-3-(5-fluoro-1H-indol-3-yl)propanoic acid; DL-5-Fluorotryptophan, N-Boc-protected
EINECS	Contact for details

Quality Control

Our 2-[(tert-Butoxycarbonyl)Amino]-3-(5-Fluoro-1H-Indol-3-Yl)Propanoic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and specific tests for residual solvents and moisture content. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable consistency and traceability for your research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under dry, inert conditions for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.