Description

n-(4-Fluoro-3-Nitrophenyl)Maleimide is a high-purity, functionalized maleimide derivative characterized by its reactive double bond and electron-withdrawing nitro and fluoro substituents. This compound is a critical building block in advanced organic synthesis, enabling the creation of complex molecules with tailored properties. It is primarily sought after by R&D chemists and process engineers in the pharmaceutical and agrochemical industries for the development of novel active ingredients and specialty polymers.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of targeted small-molecule drugs, particularly those requiring maleimide-based conjugation or specific aromatic fluoronitro motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where its structure contributes to biological activity and stability.
• Polymer Modification: Acts as a reactive monomer or cross-linking agent for engineering plastics, epoxy resins, and specialty coatings to enhance thermal and chemical resistance.
• Bioconjugation Chemistry: Employed in the development of antibody-drug conjugates (ADCs) and protein labeling reagents due to the selective reactivity of the maleimide group with thiols.
• Material Science Research: Utilized in the creation of novel organic electronic materials, such as semiconductors or photoactive layers, leveraging its electron-accepting characteristics.
• Chemical Biology Probes: Functions as a scaffold for designing fluorescent probes or activity-based protein profiling (ABPP) agents to study biological systems.

Basic Information

Product Name	n-(4-Fluoro-3-Nitrophenyl)Maleimide
CAS No.	67154-40-9
Molecular Formula	C10H5FN2O4
Molecular Weight	236.16 g/mol
Synonyms	4-Fluoro-3-nitrophenylmaleimide; 1-(4-Fluoro-3-nitrophenyl)-1H-pyrrole-2,5-dione; Maleimide, N-(4-fluoro-3-nitrophenyl)-; 3-Nitro-4-fluorophenylmaleimide; N-(4-Fluoro-3-nitrophenyl)maleimide; 2,5-Pyrroledione, 1-(4-fluoro-3-nitrophenyl)-; 4-Fluoro-3-nitro-N-phenylmaleimide
EINECS	Contact for details

Quality Control

Every batch of n-(4-Fluoro-3-Nitrophenyl)Maleimide is manufactured and tested under a strict quality management system. We guarantee high purity and lot-to-lot consistency through advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to ensure compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.