Description

(3Ar,5R,6R,7R,7Ar)-5-(Acetoxymethyl)-2-Methyl-5,6,7,7A-Tetrahydro-3Ah-Pyrano[3,2-D]Thiazole-6,7-Diyl Diacetate is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex nucleoside analogs and other bioactive molecules, offering a key chiral building block for research and development. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers focused on antiviral and anticancer drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel nucleoside and nucleotide analogs for antiviral and anticancer therapies.
• Antiviral Drug Research: Used in the development of prodrugs and active pharmaceutical ingredients (APIs) targeting viral polymerases.
• Biochemical Research: Serves as a precursor for labeled compounds in metabolic pathway studies and enzyme inhibition assays.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for complex heterocyclic compounds.
• Academic Research: Utilized in organic chemistry and medicinal chemistry departments for method development and novel compound library synthesis.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing client-specific molecular entities.

Basic Information

Product Name	(3Ar,5R,6R,7R,7Ar)-5-(Acetoxymethyl)-2-Methyl-5,6,7,7A-Tetrahydro-3Ah-Pyrano[3,2-D]Thiazole-6,7-Diyl Diacetate
CAS No.	67145-37-3
Molecular Formula	C15H19NO7S
Molecular Weight	357.38 g/mol
Synonyms	5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazole-6,7-diyl diacetate; (3aR,5R,6R,7R,7aR)-Rel-5-(Acetoxymethyl)hexahydro-2-methyl-6,7-bis(acetyloxy)-3aH-pyrano[3,2-d]thiazole; 2-Methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazole-5,6,7-triyl triacetate (stereoisomer); A key intermediate for Tenofovir Alafenamide (TAF) synthesis; Pyrano[3,2-d]thiazole derivative; Nucleoside analog intermediate; Chiral acetoxymethyl pyranothiazole.
EINECS	Contact for details

Quality Control

Our (3Ar,5R,6R,7R,7Ar)-5-(Acetoxymethyl)-2-Methyl-5,6,7,7A-Tetrahydro-3Ah-Pyrano[3,2-D]Thiazole-6,7-Diyl Diacetate is manufactured under strict quality management systems. Products undergo rigorous analytical testing, including chiral HPLC and NMR, to ensure high stereochemical purity and chemical identity. Certificates of Analysis (COA) detailing purity, chiral excess, and impurity profiles are provided with each batch. Production can adhere to cGMP guidelines for advanced pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); ensure containers are sealed under an inert atmosphere such as nitrogen or argon after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.