Description

L-2,2-Dimethylthiazolidine-4-Carboxylic Acid Hydrochloride is a high-purity, protected cysteine derivative used as a critical building block in advanced organic synthesis. This compound is essential for ensuring the stability and controlled reactivity of cysteine residues during complex peptide and protein synthesis. It is primarily required by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in the development of peptide-based therapeutics, enzyme inhibitors, and other bioactive molecules.

Application

• Peptide Synthesis: Serves as a key protected intermediate for the controlled incorporation of cysteine into peptide chains, preventing unwanted disulfide bond formation during synthesis.
• Pharmaceutical Intermediates: Used in the research and development of novel drug candidates, particularly in oncology, neurology, and metabolic disease research.
• Bioconjugation Chemistry: Acts as a precursor for creating thiol-reactive probes and linkers used in antibody-drug conjugates (ADCs) and diagnostic agents.
• Biochemical Research: Employed in studies of protein folding, structure-activity relationships (SAR), and enzyme mechanisms where specific cysteine modification is required.
• Protecting Group Strategy: The dimethylthiazolidine (Dmt) group provides robust protection for the thiol and carboxylic acid functionalities under standard peptide coupling conditions.

Basic Information

Product Name	L-2,2-Dimethylthiazolidine-4-Carboxylic Acid Hydrochloride
CAS No.	67089-92-3
Molecular Formula	C6H12ClNO2S
Molecular Weight	197.68 g/mol
Synonyms	L-Cysteine, S,S-(2,2-dimethyltrimethylene) ester, hydrochloride; Dmt-Cys-OH.HCl; (2R,4R)-2,2-Dimethylthiazolidine-4-carboxylic acid hydrochloride; (R,R)-2,2-Dimethylthiazolidine-4-carboxylic acid hydrochloride; L-2,2-Dimethyl-1,3-thiazolidine-4-carboxylic acid hydrochloride; Fmoc-Cys(Dmt)-OH (precursor); Protected L-Cysteine hydrochloride derivative
EINECS	Contact for details

Quality Control

Our L-2,2-Dimethylthiazolidine-4-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and identity confirmation via IR and NMR. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with the stringent requirements of research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.