Description

Dehydroepiandrosterone-16,16-D2 is a deuterium-labeled analog of the endogenous steroid hormone Dehydroepiandrosterone (DHEA), specifically labeled at the 16,16 positions. This compound is a critical analytical standard used as an internal reference for precise quantification and metabolic pathway tracing in sophisticated research. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in advanced steroid metabolism, pharmacokinetic studies, and clinical diagnostics.

Application

• Internal Standard for Mass Spectrometry: Essential for the accurate quantification of endogenous DHEA and its metabolites in biological matrices (e.g., serum, plasma, urine) via LC-MS/MS and GC-MS methods.
• Metabolic Pathway Research: Used as a stable isotope tracer to study the biosynthesis, biotransformation, and clearance pathways of DHEA in vitro and in vivo.
• Clinical Research and Diagnostics: Supports the development and validation of high-sensitivity assays for hormonal profiling, endocrine disorder research, and anti-doping testing.
• Pharmaceutical Development: Facilitates drug metabolism and pharmacokinetic (DMPK) studies for novel therapeutics targeting steroidogenic pathways.
• Forensic Analysis: Employed in forensic toxicology for the definitive identification and measurement of steroid hormones.
• Quality Control Reference: Serves as a certified reference material (CRM) for calibrating analytical instruments and ensuring data integrity in regulated laboratories.

Basic Information

Product Name	Dehydroepiandrosterone-16,16-D2
CAS No.	67034-83-7
Molecular Formula	C19H26D2O2
Molecular Weight	290.44 g/mol
Synonyms	DHEA-16,16-D2; 3β-Hydroxy-5-androsten-17-one-16,16-D2; 5-Androsten-3β-ol-17-one-16,16-D2; Prasterone-16,16-D2; Dehydroisoandrosterone-16,16-D2; 3β-Hydroxyandrost-5-en-17-one-16,16-D2; (3β)-3-Hydroxyandrost-5-en-17-one-16,16-D2; trans-Dehydroandrosterone-16,16-D2
EINECS	Contact for details

Quality Control

Our Dehydroepiandrosterone-16,16-D2 is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity, isotopic purity (D-enrichment), and identity confirmation via advanced spectroscopic techniques. We adhere to ISO-guided standards to guarantee batch-to-batch consistency and traceability for research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.