Description

3-Methylisothiazole-5-Carboxylic Acid is a versatile heterocyclic building block and key synthetic intermediate prized for its reactive carboxylic acid functional group fused to a substituted isothiazole ring. This compound matters for its critical role in the synthesis of complex molecules, particularly in the development of pharmaceuticals and advanced agrochemicals. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, where the isothiazole moiety can impart specific biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis and metal complexation.
• Material Science Research: Employed in the development of functional polymers, dyes, and other advanced materials that require heterocyclic components.
• Chemical Biology Probes: Utilized as a scaffold for designing molecular probes and inhibitors to study enzymatic activity and biological pathways.

Basic Information

Product Name	3-Methylisothiazole-5-Carboxylic Acid
CAS No.	66975-83-5
Molecular Formula	C5H5NO2S
Molecular Weight	143.16 g/mol
Synonyms	5-Carboxy-3-methylisothiazole; 3-Methyl-5-isothiazolecarboxylic acid; 3-Methyl-1,2-thiazole-5-carboxylic acid; 3-Methylisothiazole-5-carboxylic acid; 3-Methyl-5-carboxyisothiazole; MI5CA; 3-Methyl-1,2-thiazol-5-yl carboxylic acid
EINECS	Contact for details

Quality Control

Our 3-Methylisothiazole-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.