Description

17Beta-Estradiol-2,4,16,16-D4 is a high-purity, deuterium-labeled internal standard of the primary female sex hormone, estradiol. This stable isotope-labeled compound is critical for ensuring accuracy and reliability in quantitative analytical methods, particularly mass spectrometry. It is an essential reagent for researchers and quality control laboratories in the pharmaceutical, clinical diagnostics, and environmental monitoring sectors who require precise measurement of estradiol levels.

Application

• Quantitative Mass Spectrometry: Serves as a deuterated internal standard for the accurate quantification of endogenous 17β-Estradiol in complex biological matrices (e.g., serum, plasma, tissue).
• Pharmaceutical R&D and Bioanalysis: Used in pharmacokinetic (PK) and pharmacodynamic (PD) studies for drug candidates targeting estrogen pathways, ensuring precise measurement of drug and hormone levels.
• Clinical Research and Diagnostics: Enables reliable measurement of estradiol in patient samples for research into endocrine disorders, fertility studies, and hormone replacement therapy monitoring.
• Environmental and Food Safety Testing: Applied as a reference standard in LC-MS/MS methods to detect and quantify trace levels of estrogenic compounds in water, soil, and food products.
• Method Development and Validation: A key component for developing, calibrating, and validating highly sensitive and specific analytical assays in compliance with GLP and ISO 17025 standards.

Basic Information

Product Name	17Beta-Estradiol-2,4,16,16-D4
CAS No.	66789-03-5
Molecular Formula	C18H20D4O2
Molecular Weight	276.40 g/mol
Synonyms	Estradiol-d4; [2,4,16,16-2H4]-17β-Estradiol; Deuterated Estradiol; 17β-Estradiol-2,4,16,16-d4; E2-d4; (17β)-Estra-1,3,5(10)-triene-3,17-diol-2,4,16,16-d4; 1,3,5(10)-Estratrien-3,17β-diol-2,4,16,16-d4
EINECS	Contact for details

Quality Control

Every batch of 17Beta-Estradiol-2,4,16,16-D4 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing performed using advanced techniques including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) providing batch-specific data on purity, isotopic enrichment, and impurities is supplied with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.