Description

4-Bromo-1-Chloroisoquinoline is a versatile halogenated isoquinoline derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its unique bifunctional halogen pattern enables selective cross-coupling reactions and scaffold diversification, making it a valuable building block for complex molecule construction. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, particularly for developing active pharmaceutical ingredients (APIs) and functional organic materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other biologically active heterocycles.
• Agrochemical Research: Used as a building block for developing new pesticides and herbicides with specific modes of action.
• Material Science: Serves as a monomer or functional unit in the creation of organic semiconductors, ligands for catalysis, and specialty polymers.
• Cross-Coupling Reactions: The bromo and chloro substituents allow for sequential, site-selective Suzuki, Stille, or Buchwald-Hartwig amination reactions.
• Ligand Synthesis: Useful for constructing complex chelating ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and cellular processes.

Basic Information

Item	Detail
Product Name	4-Bromo-1-Chloroisoquinoline
CAS No.	66728-98-1
Molecular Formula	C9H5BrClN
Molecular Weight	242.50 g/mol
Synonyms	1-Chloro-4-bromoisoquinoline; 4-Bromo-1-chloro-isoquinoline; Isoquinoline, 4-bromo-1-chloro-; 4-Bromo-1-chloroisoquinoline; 66728-98-1; 1-Chloro-4-bromoisoquinoline; 4-Bromo-1-Cl-isoquinoline
EINECS	Contact for details

Quality Control

Our 4-Bromo-1-Chloroisoquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and GC-MS for impurity profiling, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Handle and store in accordance with all applicable regulations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.