Description

(+)-6,7,8,9-Tetrahydro-3,5,5,9-Tetramethyl-5H-Benzocyclohepten-1-Ol CAS NO 66656-01-7 is a high-purity, optically active benzocycloheptenol derivative that serves as a critical chiral building block and intermediate in advanced organic synthesis. Its unique fused ring structure and stereochemistry make it valuable for constructing complex molecular architectures with precise spatial orientation. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for developing novel active pharmaceutical ingredients (APIs) and specialty materials.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of new therapeutic agents, including central nervous system (CNS) drugs and anti-inflammatory compounds.
• Asymmetric Synthesis: Employed as a building block in stereoselective reactions to introduce the benzocycloheptenol moiety into target molecules.
• Fragrance and Flavor Chemistry: Potential precursor for the synthesis of novel aroma chemicals with complex, woody, or amber notes due to its polycyclic structure.
• Material Science Research: Investigated as a monomer or functional additive for creating specialized polymers with unique optical or mechanical properties.
• Agrochemical Development: Intermediate in the synthesis of novel, high-value crop protection agents and pesticides.
• Academic and R&D: Used in methodological studies and as a reference standard in chemical research laboratories worldwide.

Basic Information

Product Name	(+)-6,7,8,9-Tetrahydro-3,5,5,9-Tetramethyl-5H-Benzocyclohepten-1-Ol
CAS No.	66656-01-7
Molecular Formula	C15H22O
Molecular Weight	218.33 g/mol
Synonyms	(+)-6,7,8,9-Tetrahydro-3,5,5,9-tetramethyl-1H-benzocyclohepten-1-ol; (1R)-6,7,8,9-Tetrahydro-3,5,5,9-tetramethyl-5H-benzocyclohepten-1-ol; (+)-Ambrox; (1R)-Ambrox; (R)-Ambrox; (1R,5R,9S)-2,6,6,9-Tetramethyltricyclo[5.4.0.02,8]undecan-1-ol (related tricyclic name); Ambrox DL; (+)-Tetrahydroambrox; Ambroxide precursor.
EINECS	Contact for details

Quality Control

Our production of (+)-6,7,8,9-Tetrahydro-3,5,5,9-Tetramethyl-5H-Benzocyclohepten-1-Ol adheres to stringent quality management protocols. Every batch is characterized and tested to ensure identity, purity, and enantiomeric excess meet exacting standards. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for key parameters including assay, optical rotation, and impurity profile. We support cGMP and ISO 9001 compliant manufacturing for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	+ Specific value provided on COA
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.