Description

(5Alpha,6Alpha)-4,5-Epoxy-3-Hydroxy-17-Methylmorphinan-6-Yl Acetate is a high-purity synthetic opioid derivative of significant interest in advanced pharmaceutical research and development. This compound matters as a critical intermediate for the synthesis of specialized analgesics and for pharmacological studies targeting the central nervous system. It is primarily needed by pharmaceutical R&D laboratories, analytical reference standard producers, and manufacturers engaged in the development of controlled substance APIs.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the production of potent opioid analgesics and their derivatives.
• Reference Standard: Used as a high-purity certified reference material (CRM) for analytical method development, validation, and quality control testing in pharmaceutical and forensic laboratories.
• Pharmacological Research: Employed in preclinical studies to investigate opioid receptor binding affinity, metabolic pathways, and structure-activity relationships (SAR).
• Controlled Substance Synthesis: A vital building block in the licensed, GMP-compliant manufacture of Schedule II narcotic active pharmaceutical ingredients (APIs).
• Metabolite Studies: Utilized in the synthesis and identification of specific drug metabolites for toxicological and pharmacokinetic research.

Basic Information

Product Name	(5Alpha,6Alpha)-4,5-Epoxy-3-Hydroxy-17-Methylmorphinan-6-Yl Acetate
CAS No.	66641-10-9
Molecular Formula	C20H25NO4
Molecular Weight	343.42 g/mol
Synonyms	14-Hydroxymorphinone acetate; 14-Hydroxymorphinone 6-acetate; 4,5α-Epoxy-3,14-dihydroxy-17-methylmorphinan-6α-yl acetate; 6-Acetoxy-14-hydroxymorphinone; Noroxymorphone 6-acetate; 14-Hydroxy-6-acetoxymorphinone
EINECS	Contact for details

Quality Control

Our (5Alpha,6Alpha)-4,5-Epoxy-3-Hydroxy-17-Methylmorphinan-6-Yl Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.