Description

(R)-(+)-Ketorolac CAS NO 66635-93-6 is the pharmacologically active enantiomer of the potent non-steroidal anti-inflammatory drug (NSAID) ketorolac. This high-purity chiral building block is critical for the development and production of enantiomerically pure pharmaceutical formulations. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract research organizations (CROs) engaged in advanced analgesic and anti-inflammatory drug development.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: A key chiral synthon in the synthesis of enantiopure (R)-Ketorolac tromethamine, the active form used in pharmaceutical products.
• Pharmaceutical Research & Development: Used in preclinical and clinical studies to investigate the specific pharmacokinetics, efficacy, and safety profile of the (R)-enantiomer.
• Chiral Reference Standard: Serves as a high-purity standard for analytical method development, validation, and quality control in HPLC and chiral separation techniques.
• Asymmetric Synthesis Studies: Employed as a model compound in research focused on novel chiral resolution methods and asymmetric catalytic processes.
• Formulation Development: Used in the development of specialized drug delivery systems, such as ophthalmic solutions or injectables, requiring the single enantiomer.

Basic Information

Product Name	(R)-(+)-Ketorolac
CAS No.	66635-93-6
Molecular Formula	C15H13NO3
Molecular Weight	255.27 g/mol
Synonyms	(+)-(R)-Ketorolac; (R)-Ketorolac; Dexketoprofen (Note: Different compound, sometimes confused); 5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid, (R)-form; (R)-5-Benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid; (2R)-2-[(1,4-Dihydro-1,4-dioxonaphthalen-2-yl)oxy]propanoic acid (Incorrect IUPAC for a different structure, but sometimes listed); The active enantiomer of Ketorolac.
EINECS	Contact for details

Quality Control

Our (R)-(+)-Ketorolac is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets stringent specifications for pharmaceutical R&D use. A Certificate of Analysis (COA) detailing identity, purity (typically >98.5% by HPLC), enantiomeric excess (ee), and related substances is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.