Description

5-Methoxytryptamine-A,A,B,B-D4 Hcl is a high-purity, deuterium-labeled analog of 5-methoxytryptamine hydrochloride, a key compound in neurochemical research. This stable isotope-labeled derivative is essential for use as an internal standard in quantitative mass spectrometry, ensuring precise and accurate analytical measurements. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in metabolomics, pharmacokinetic studies, and neurotransmitter pathway analysis.

Application

• Internal Standard for LC-MS/MS: Critical for the quantitative analysis of 5-methoxytryptamine and related indoleamines in complex biological matrices like plasma, serum, and cerebrospinal fluid.
• Metabolomics Research: Enables precise tracking and quantification of tryptamine metabolic pathways in disease model studies.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Used to determine the absorption, distribution, metabolism, and excretion (ADME) profiles of serotonergic compounds.
• Neurochemical Assay Development: Serves as a reference standard in the development and validation of high-sensitivity assays for neurotransmitters.
• Isotope Dilution Mass Spectrometry (IDMS): Provides the gold-standard method for achieving high accuracy and minimizing matrix effects in analytical chemistry.
• Biomarker Discovery and Validation: Facilitates the accurate measurement of potential biomarkers related to neurological and psychiatric conditions.

Basic Information

Product Name	5-Methoxytryptamine-A,A,B,B-D4 Hcl
CAS No.	66521-35-5
Molecular Formula	C11H11D4ClN2O
Molecular Weight	226.75 g/mol
Synonyms	5-Methoxy-D4-tryptamine hydrochloride; 5-MeO-D4-Tryptamine HCl; 5-Methoxytryptamine-α,α,β,β-d4 hydrochloride; 3-(2-Aminoethyl)-5-methoxyindole-α,α,β,β-d4 hydrochloride; 5-MT-d4 HCl; Deuterated 5-Methoxytryptamine HCl; 5-Methoxy-[α,α,β,β-2H4]tryptamine hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 5-Methoxytryptamine-A,A,B,B-D4 Hcl is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure exceptional isotopic purity and chemical identity. Our quality commitment includes comprehensive characterization by NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) are provided with each shipment, detailing batch-specific results for isotopic enrichment, chemical purity, and other critical parameters to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a cool, dry place. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere after each use to maintain long-term stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D4)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.