Description

Dimethyl Fumarate D6 is a deuterium-labeled isotopologue of dimethyl fumarate, a compound of significant interest in pharmaceutical research and development. This stable isotope-labeled analog is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical measurements. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of dimethyl fumarate and its metabolites in complex biological matrices such as plasma, serum, and tissue homogenates.
• Pharmacokinetic and Metabolite Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Serves as a key component in developing robust, regulatory-compliant analytical methods for drug development pipelines.
• Drug Impurity Profiling and Degradation Studies: Used as a reference standard to identify and quantify potential impurities or degradation products in active pharmaceutical ingredient (API) batches.
• Stable Isotope Dilution Assays: Provides superior accuracy over conventional internal standards in advanced mass spectrometric analyses due to nearly identical chemical properties.

Basic Information

Product Name	Dimethyl Fumarate D6
CAS No.	66487-95-4
Molecular Formula	C6D6O4
Molecular Weight	158.17 g/mol
Synonyms	Dimethyl (E)-2-butenedioate-d6; (2E)-But-2-enedioic acid-d6 dimethyl ester; Deuterated Dimethyl Fumarate; DMF-d6; Dimethyl Fumarate-d6; Hexadeuterodimethyl fumarate; Methyl hydrogen fumarate-d6 derivative; Fumaric Acid Dimethyl Ester-d6
EINECS	Contact for details

Quality Control

Every batch of our Dimethyl Fumarate D6 is manufactured and analyzed under strict quality management protocols to ensure it meets the exacting standards required for analytical and research applications. We guarantee high chemical and isotopic purity, with comprehensive testing performed using advanced techniques including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic enrichment, and all relevant analytical data.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.