Description

Boc-Lys(2-Chloro-Z)-Osu is a specialized, protected amino acid derivative widely used as a key building block in peptide synthesis. This compound matters for its role in facilitating the controlled and sequential assembly of complex peptides, particularly where orthogonal protection strategies are required. Pharmaceutical researchers and fine chemical manufacturers need it for the development of therapeutic peptides, bioactive probes, and advanced research compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A crucial intermediate for the controlled incorporation of lysine residues with orthogonal side-chain protection.
• Solution-Phase Peptide Synthesis: Used in the synthesis of complex peptide sequences and small protein fragments in solution.
• Pharmaceutical Intermediates: Serves as a key raw material in the production of active pharmaceutical ingredients (APIs) for peptide-based drugs.
• Bioconjugation and Labeling: Facilitates the site-specific attachment of labels, tags, or other molecules to peptides via the reactive N-hydroxysuccinimide (Osu) ester group.
• Research & Development: Essential for academic and industrial R&D in medicinal chemistry, chemical biology, and proteomics for creating novel peptide structures.
• Custom Peptide Services: A fundamental reagent for CROs and CDMOs offering custom peptide synthesis services to the biotech and pharmaceutical industries.

Basic Information

Item	Detail
Product Name	Boc-Lys(2-Chloro-Z)-Osu
CAS No.	66438-39-9
Molecular Formula	C25H36ClN3O8
Molecular Weight	542.02 g/mol
Synonyms	Nα-Boc-Nε-(2-Chlorobenzyloxycarbonyl)-L-lysine N-hydroxysuccinimide ester; Boc-Lys(2-Cl-Z)-OSu; (2S)-6-[[(2-Chlorophenyl)methoxy]carbonylamino]-2-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid 2,5-dioxopyrrolidin-1-yl ester; N-α-(tert-Butoxycarbonyl)-N-ε-(2-chlorobenzyloxycarbonyl)-L-lysine N-succinimidyl ester; Boc-Lys(2-Cl-Cbz)-OSu; Boc-L-Lys(2-Cl-Z)-OSu; N-Boc-N'-2-chloro-Z-L-lysine N-hydroxysuccinimide ester
EINECS	Contact for details

Quality Control

Our Boc-Lys(2-Chloro-Z)-Osu is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile; slightly soluble in dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.