Description

1-[(S)-2-Amino-1-Oxopropyl]-5-Bromo-2,3-Dihydro-7-Nitro-1H-Indole is a high-purity, chiral indole derivative of significant interest in advanced organic synthesis. This compound serves as a critical pharmaceutical intermediate and a versatile building block for research into novel bioactive molecules. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop new therapeutic agents or functional materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) targets.
• Medicinal Chemistry Research: Used as a core scaffold for constructing compound libraries in drug discovery programs to explore structure-activity relationships (SAR).
• Asymmetric Synthesis: Employed as a chiral precursor or reagent in stereoselective synthesis due to its defined (S)-configuration at the amino acid moiety.
• Agrochemical Development: Serves as a building block for novel herbicides, fungicides, or plant growth regulators.
• Biochemical Probe Synthesis: Utilized in the creation of labeled compounds or probes for biological and pharmacological studies.
• Fine Chemical Manufacturing: Acts as a specialized intermediate for producing high-value, complex organic molecules.

Basic Information

Product Name	1-[(S)-2-Amino-1-Oxopropyl]-5-Bromo-2,3-Dihydro-7-Nitro-1H-Indole
CAS No.	66414-93-5
Molecular Formula	C11H12BrN3O3
Molecular Weight	314.14 g/mol
Synonyms	5-Bromo-7-nitro-2,3-dihydro-1H-indole-1-(S)-2-aminopropanamide; (S)-2-Amino-N-(5-bromo-7-nitro-2,3-dihydro-1H-indol-1-yl)propanamide; 5-Bromo-7-nitroindoline-1-carboxamide, L-alanine derivative; L-Alaninamide, N-(5-bromo-7-nitro-2,3-dihydro-1H-indol-1-yl)-; 66414-93-5; A chiral nitro-bromo indoline derivative
EINECS	Contact for details

Quality Control

Our 1-[(S)-2-Amino-1-Oxopropyl]-5-Bromo-2,3-Dihydro-7-Nitro-1H-Indole is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure high chemical and enantiomeric purity suitable for research and development applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.